LDN inhibits receptors for just a few hours, and after that, it is excreted. The lower dose of naltrexone acts as an inducer of the “rebound” effect that continues for nearly one day. But with higher doses, this effect cannot be obtained. Once the medicine is excreted from the body, the sensitized receptors are capable of utilizing the increased endorphins in a better way. Low-dose naltrexone results in more efficient utilization and better production of OGF.